Rh(III)-Catalyzed Divergent Synthesis of Alkynylated Imidazo[1,5-<i>a</i>]indoles and α,α-Difluoromethylene Tetrasubstituted Alkenes
Fei Zhao, Qiao Jin, Yangbin Lu, Xiaoning Zhang, Long Dai, Xin Gong, Hui Mao, Shiyao Lu, Xiaowei Wu, Siyu Liu
Abstract
]indoles and α,α-difluoromethylene tetrasubstituted alkenes through Rh(III)-catalyzed [4 + 1] annulation/alkyne moiety migration and C-H alkenylation/DG migration, respectively. This protocol features tunable product selectivity, excellent chemo-, regio-, and stereoselectivity, broad substrate scope, moderate to high yields, good tolerance of functional groups, and mild redox-neutral conditions.
Topics & Concepts
ChemistryMoietyStereoselectivityAlkyneCatalysisAnnulationSubstrate (aquarium)Combinatorial chemistrySelectivityDivergent synthesisMedicinal chemistryStereochemistryOrganic chemistryGeologyOceanographyCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsFluorine in Organic Chemistry