Cerebral perfusion in untreated, controlled, and uncontrolled hypertension
Isabel N. Christie, Rowan Windsor, Henk Mutsaerts, Therese Tillin, Carole H. Sudre, Alun D. Hughes, Xavier Golay, Alexander V. Gourine, Patrick S. Hosford
Abstract
This study evaluated the association between systemic arterial blood pressure and cerebral perfusion in 740 participants of the UK's largest tri-ethnic study with measurements of cerebral blood flow (CBF) performed using arterial spin labelling MRI. A significant negative correlation between blood pressure, age and CBF was observed across the patient cohort. The lowest CBF values were recorded in the group of patients with hypertension that were prescribed with anti-hypertensive drugs, but uncontrolled on medication. These findings confirm that hypertension is associated with reduced cerebral perfusion and highlight the importance of blood pressure control for the benefit of maintaining brain blood flow.