NMDA receptor–BK channel coupling regulates synaptic plasticity in the barrel cortex
Ricardo Gómez, Laura E. Maglio, Alberto J. Gonzalez-Hernandez, Belinda Rivero-Pérez, David Bartolomé‐Martín, Teresa Giráldez
Abstract
efflux and strong negative feedback inhibition. We further show that neurons exhibiting such NMDAR-BK coupling serve as high-pass filters for incoming synaptic inputs, precluding the induction of spike timing-dependent plasticity. Together, these data suggest that NMDAR-localized BK channels regulate synaptic integration and provide input-specific synaptic diversity to a thalamocortical circuit.
Topics & Concepts
Postsynaptic potentialNeuroscienceNonsynaptic plasticitySynaptic plasticityNMDA receptorMetaplasticityBK channelChemistryBiophysicsBiologyReceptorMembrane potentialBiochemistryNeuroscience and Neuropharmacology ResearchAdvanced Memory and Neural ComputingNeural dynamics and brain function