Anti-inflammatory sesquiterpenoids from the leaves of Datura metel L.
Jin‐Yan Tan, Yan Liu, Yan‐Gang Cheng, Yanping Sun, Juan Pan, Shihui Yang, Haixue Kuang, Bing‐You Yang
Abstract
Nine new (1–9) and three known (10−12) sesquiterpenoids were isolated from the ethanol-water (7:3, v/v) extract of the Datura metel L. leaves. The structures of 1–9 were elucidated by detailed spectroscopic analyses, including 1D and 2D NMR, HR-ESI-MS. All isolates (1−12) were evaluated for anti-inflammatory activity against the production of nitrogen oxide in lipopolysaccharide-induced RAW264.7 cells and compound 5 possessed the best inhibitory effect among them, with the IC50 value reaching 9.33–11.67 μM, which was lower than positive control, L-NMMA, with IC50 range from 13.64 to 17.02 μM.
Topics & Concepts
IC50ChemistryTraditional medicineLipopolysaccharideSolanaceaeAnti-inflammatoryBotanyBiologyIn vitroBiochemistryPharmacologyMedicineEndocrinologyGenePhytochemicals and Medicinal PlantsMedicinal Plants and NeuroprotectionEssential Oils and Antimicrobial Activity