Colon‐Targeted Adhesive Hydrogel Microsphere for Regulation of Gut Immunity and Flora (Adv. Sci. 18/2021)
Hua Liu, Zhengwei Cai, Fei Wang, Liwen Hong, Lianfu Deng, Jie Zhong, Zhengting Wang, Wenguo Cui
Abstract
Colon‐Targeted Drug Delivery In article number 2101619 by Jie Zhong, Zhengting Wang, Wenguo Cui, and co‐workers, a targeted blasting and adhesive hydrogel microsphere with core‐shell structure is designed for oral administrated inflammatory bowel disease treatment, with a calcium alginate hydrogel shell that targets the colon to “blast” and release the core, and an HA‐SH‐Ag hydrogel core that congregates on the inflamed colon mucosa regulating macrophage differentiation and optimizing the composition of gut flora. [Image: see text]
Topics & Concepts
MicrosphereSelf-healing hydrogelsAdhesiveGut floraInflammatory bowel diseaseMacrophageFlora (microbiology)MedicineChemistryImmunologyMaterials scienceNanotechnologyChemical engineeringPathologyDiseaseBiologyBacteriaBiochemistryIn vitroPolymer chemistryGeneticsEngineeringLayer (electronics)Medical and Biological Ozone ResearchPediatric health and respiratory diseases