Boryl radical-mediated halogen-atom transfer (XAT) enables the Sonogashira-like alkynylation of alkyl halides
Javier Corpas, Maialen Alonso, Daniele Leonori
Abstract
The Sonogashira-like alkynylation of alkyl halides is achieved by a photocatalytic approach exploiting amine-ligated boryl radicals as halogen-atom transfer mediators in combination with alkynyl sulfones as SOMOphilic reagents.
Topics & Concepts
Sonogashira couplingAlkynylationHalideAlkylHalogenChemistryAtom (system on chip)Combinatorial chemistryOrganic chemistryCatalysisPalladiumComputer scienceEmbedded systemRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling Reactions