Nucleophosmin Plays a Role in Repairing DNA Damage and Is a Target for Cancer Treatment
Konjeti R. Sekhar, Michael L. Freeman
Abstract
Nucleophosmin (NPM1) is frequently mutated in acute myeloid leukemia, and NPM1 expression is elevated in several cancer types. NPM1 is a multifunctional oligomeric protein involved in numerous cellular functions that include participating in liquid-liquid phase separation, ribosome biogenesis, chaperoning of histones, and modulation of transcription. In this review, we discuss the underappreciated role of NPM1 in DNA damage repair, specifically Polη-mediated translesion synthesis, base excision, and homologous recombination and highlight the therapeutic potential of NPM1 targeting in cancer treatment.
Topics & Concepts
NucleophosminNPM1DNA damageRibosome biogenesisHomologous recombinationDNA repairHistoneMyeloid leukemiaChromatinCancer researchBiologyDNABase excision repairCell biologyChemistryGeneticsRibosomeRNAGeneChromosomeKaryotypeAcute Myeloid Leukemia ResearchDNA Repair MechanismsAcute Lymphoblastic Leukemia research