Insights into the hepatotoxicity of pyrene and 1-chloropyrene using an integrated approach of metabolomics and transcriptomics
Yun Luo, Baoqin Zhang, Ningbo Geng, Shuai Sun, Xiaoyao Song, Jiping Chen, Haijun Zhang
Topics & Concepts
Aryl hydrocarbon receptorOxidative phosphorylationGlycolysisChemistryMetabolic pathwayMetabolomicsPyreneBiochemistryBeta oxidationTranscriptomeMetabolismBenzo(a)pyreneFatty acidMetabolic intermediateCarcinogenGene expressionGeneTranscription factorOrganic chemistryChromatographyToxic Organic Pollutants ImpactMetabolomics and Mass Spectrometry StudiesPharmacogenetics and Drug Metabolism