Molecular insights into the inhibition mechanism of harringtonine against essential proteins associated with SARS-CoV-2 entry
Zhiwei Yang, Xinyue Fu, Yizhen Zhao, Xuhua Li, Jiangang Long, Lei Zhang
Topics & Concepts
TMPRSS2CoronavirusDocking (animal)ChemistryTransmembrane proteinProteasesViral entryReceptorSmall moleculeMechanism of actionMechanism (biology)Plasma protein bindingSerine proteaseProteaseTransmembrane domainEnzymeBiologyBiochemistryVirusCoronavirus disease 2019 (COVID-19)In vitroVirologyViral replicationMedicineInfectious disease (medical specialty)EpistemologyDiseasePhilosophyNursingPathologyComputational Drug Discovery MethodsRNA and protein synthesis mechanismsSARS-CoV-2 and COVID-19 Research