Catalytic defluorinative ketyl–olefin coupling by halogen-atom transfer
Peter Bellotti, Huan‐Ming Huang, Teresa Faber, Ranjini Laskar, Frank Glorius
Abstract
-difluorohomoallylic alcohols under mild conditions with broad substrate scope. Preliminary mechanistic experimental and computational studies demonstrate that this radical-to-polar crossover transformation could be achieved by sequentially orchestrated Lewis acid activation, halogen-atom transfer, radical addition, single-electron reduction and β-fluoro elimination.
Topics & Concepts
KetylOlefin fiberChemistryCatalysisHalogenElectron transferPhotochemistryCoupling (piping)ElectrosynthesisCombinatorial chemistryOrganic chemistryBenzophenoneMaterials scienceAlkylElectrochemistryPhysical chemistryMetallurgyElectrodeRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsFluorine in Organic Chemistry