Apigenin-7-<i>O</i>-<i>β</i>-D-(-6”-<i>p</i>-coumaroyl)-glucopyranoside treatment elicits a neuroprotective effect through GSK-3β phosphorylation-mediated Nrf2 activation
Jingwen Wang, Shiquan Wang, Sisi Sun, Yunyang Lu, Kai Gao, Chao Guo, Ruili Li, Weiwei Li, Xian Zhao, Haifeng Tang, Aidong Wen, Min Cai, Wei Zhang
Abstract
APG improved neurological scores and reduced infarct volume. APG increased GSK-3β phosphorylation and Nrf2 nuclear translocation, while these effects were prevented by PI3K inhibitors or Nrf2-siRNA treatment in both OGD/R cell cultures and ischemic/reperfusion rats. These findings reveal that GSK-3β phosphorylation-mediated Nrf2 activation is involved in the neuroprotective effect of APG.
Topics & Concepts
NeuroprotectionApigeninPhosphorylationChemistryPharmacologyStereochemistryMedicineBiochemistryFlavonoidAntioxidantGenomics, phytochemicals, and oxidative stressPhytochemicals and Antioxidant ActivitiesFree Radicals and Antioxidants