A time course for markers of protein synthesis and degradation with hindlimb unloading and the accompanying anabolic resistance to refeeding
Paul A. Roberson, Kevin L. Shimkus, Jaclyn E. Welles, Dandan Xu, Abigale L. Whitsell, Eric M. Kimball, Leonard S. Jefferson, Scot R. Kimball
Abstract
Hindlimb unloading causes significant skeletal muscle atrophy by adversely affecting the balance between protein synthesis and breakdown. This study demonstrates a more complete time course for changes in biomarkers associated with protein synthesis and breakdown and investigates the associated anabolic resistance to an anabolic stimulus following hindlimb unloading. These data in concert with information from other studies provide a basis for designing future experiments to optimally interrogate a desired cellular biomarker or pathway.
Topics & Concepts
AnabolismHindlimbMuscle atrophyProtein degradationProtein catabolismAtrophyBiologySkeletal muscleEndocrinologyInternal medicineChemistryMedicineCell biologyBiochemistryAmino acidMuscle Physiology and DisordersMuscle metabolism and nutritionMuscle activation and electromyography studies