Human cancer germline antigen-specific cytotoxic T cell—what can we learn from patient
Megat Abd Hamid, Yanchun Peng, Tao Dong
Abstract
Abstract In this review, we will highlight the importance of cancer germline antigen-specific cytotoxic CD8 + T lymphocytes (CTL) and the factors affecting antitumor CTL responses. In light of cancer immunotherapy, we will emphasis the need to further understand the features, characteristics, and actions of modulatory receptors of human cancer germline-specific CTLs, in order to determine the optimal conditions for antitumor CTL responses.
Topics & Concepts
CTL*Cytotoxic T cellGermlineCancerImmunotherapyAntigenImmunologyCancer immunotherapyCD8Cancer researchBiologyImmune systemMedicineGeneticsIn vitroGeneCancer Immunotherapy and BiomarkersImmune Cell Function and InteractionCAR-T cell therapy research