Redox-sensitive cyclophilin A elicits chemoresistance through realigning cellular oxidative status in colorectal cancer
Liyuan Peng, Jingwen Jiang, Hai‐Ning Chen, Li Zhou, Zhao Huang, Siyuan Qin, Ping Jin, Maochao Luo, Bowen Li, Jiayan Shi, Na Xie, Lih‐Wen Deng, Yih‐Cherng Liou, Edouard C. Nice, Canhua Huang, Yuquan Wei
Abstract
and chemotherapeutics through a CypA-PRDX2-mediated antioxidant apparatus. Notably, CypA is upregulated in chemoresistant CRC samples, which predicts poor prognosis. Moreover, targeting CypA by cyclosporine A exhibits promising efficacy against chemoresistant CRC when combined with chemotherapeutics. Collectively, our findings highlight CypA as a component of cellular noncanonical antioxidant defense and as a potential druggable therapeutic target to ameliorate CRC chemoresistance.
Topics & Concepts
CypaOxidative stressCyclophilin AReactive oxygen speciesCancer researchPeroxiredoxinChemistryBiologyPharmacologyCell biologyBiochemistryMolecular biologyEnzymePeroxidaseSignaling Pathways in DiseaseExtracellular vesicles in diseaseHistone Deacetylase Inhibitors Research