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miR-221-3p and miR-222-3p downregulation promoted osteogenic differentiation of bone marrow mesenchyme stem cells through IGF-1/ERK pathway under high glucose condition

Kang Gan, Guan-hua Dong, Ning Wang, Juanfang Zhu

2020Diabetes Research and Clinical Practice49 citationsDOI

Topics & Concepts

Gene silencingRUNX2MAPK/ERK pathwayOsteoblastDownregulation and upregulationOsteopontinMesenchymemicroRNACell biologyWestern blotEndocrinologyInternal medicineMesenchymal stem cellChemistryBiologyMedicineSignal transductionGeneBiochemistryIn vitroMicroRNA in disease regulationMesenchymal stem cell researchBone Metabolism and Diseases
miR-221-3p and miR-222-3p downregulation promoted osteogenic differentiation of bone marrow mesenchyme stem cells through IGF-1/ERK pathway under high glucose condition | Litcius