AcBr/DMSO Mediated Sulfenylation of Pyrrolo[2,1-<i>a</i>]isoquinolines
Xiao‐Hui Chen, Hai‐Lei Cui
Abstract
We have developed a mild sulfenylation of pyrrolo[2,1- a ]isoquinolines with acetyl bromide and dimethyl sulfoxide. A wide range of functionalized pyrrolo[2,1- a ]isoquinolines could be prepared efficiently through the formation of a C–S bond with thiophenols (27 examples, 36–94% yields). The current strategy can also be utilized for functionalization of pyrrolo[1,2- a ]quinolines and indole.
Topics & Concepts
ChemistryIsoquinolineBromideDimethyl sulfoxideIndole testCombinatorial chemistrySurface modificationSulfoxideOrganic chemistryMedicinal chemistryPhysical chemistrySulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsSynthesis and Characterization of Pyrroles