Inhibition of PTP1B by farnesylated 2-arylbenzofurans isolated from Morus alba root bark: unraveling the mechanism of inhibition based on in vitro and in silico studies
Mạnh Tuấn Hà, Srijan Shrestha, Thu Hương Trần, Jeong Ah Kim, Mi Hee Woo, Jae Sue Choi, Byung Sun Min
Topics & Concepts
IC50Uncompetitive inhibitorPrenylationChemistryStereochemistryAllosteric regulationNon-competitive inhibitionBiochemistryDocking (animal)Inhibitory postsynaptic potentialPhytochemicalIn vitroEnzymeBiologyNursingNeuroscienceMedicineProtein Tyrosine PhosphatasesBioactive Compounds and Antitumor AgentsSynthesis of Organic Compounds