Therapeutic Potential of Equol: A Comprehensive Review
Atiya Fatima, Mohd Shariq Khan, Md. Wasi Ahmad
Abstract
Equol (4',7-isoflavandiol), is a phytoestrogenic compound, which is synthesized from parent molecule diadzein by intestinal bacterial flora. It is among one of the most extensively researched molecule due to its high affinity towards estrogen receptors. Its enantiomeric form S-equol has been explored in the treatment of estrogen/androgen mediated diseases. Various therapeutic applications such as anti-cancer, cardioprotective, antidiabetic, antiosteoporosis, anti-ageing, and neuroprotective efficacy are attributed to it. This review explored major studies related to biochemistry and pharmacological applications of equol for human health.
Topics & Concepts
EquolEstrogenEstrogen receptorAndrogen receptorPharmacologyChemistryMedicineProstate cancerCancerGenisteinInternal medicineDaidzeinBreast cancerMedicinal Plant ResearchNigella sativa pharmacological applicationsPhytochemicals and Antioxidant Activities