Genetic Variations and Frequencies of the Two Functional Single Nucleotide Polymorphisms of SLCO1B1 in the Thai Population
Chalitpon Na Nakorn, Jariya Waisayarat, Charungthai Dejthevaporn, Pornpen Srisawasdi, Sansanee Wongwaisayawan, Chonlaphat Sukasem
Abstract
Aim: To investigate the variations and the frequencies of SLCO1B1 gene in Thai population. Methods: Thai DNA samples were screened genotyping of c.388A>G and c.521T>C of the SLCO1B1 using TaqMan real-time PCR. The interpretations were categorized into five regions of Thailand. Results: The frequencies of two SNPs showed no significant in MAF among five regions, while the haplotypes of SLCO1B1*1a, *1b, *5, and *15 were 21.74, 65.39, 0.08 and 12.78%, respectively. The phenotypes of OATP1B1 transporter showed 75.85%, 22.57%, and 1.58% in normal, intermediate, and low function, which were in worldwide range. Conclusion: This study observed the variation of SLCO1B1 in Thai population that can represent the database on the function of the OATP1B1 transporter and the determination of clinical use of drugs.