Asymmetric Palladium-Catalyzed Aminochlorination of Unactivated Alkenes
Zhigang Wang, Chuanqi Hou, Pinhong Chen
Abstract
A novel Pd-catalyzed enantioselective aminochlorination of alkenes via a 6- endo cyclization is reported herein, which provides easy access to a wide array of structurally diverse 3-chloropiperidines in good yields with excellent enantioselectivities. Notably, both an electrophilic chlorination reagent (NCS) and the sterically bulky chiral pyridinyl-oxazoline (Pyox) ligand are crucial to the successful reaction.
Topics & Concepts
ChemistrySteric effectsOxazolineEnantioselective synthesisCatalysisElectrophileReagentPalladiumCombinatorial chemistryLigand (biochemistry)Organic chemistryReceptorBiochemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsVanadium and Halogenation Chemistry