Tandem Electrochemical Redox/Condensation Reaction Between 2‐Amino Nitrobenzenes and Aliphatic Alcohols: An Approach to Benzimidazoles
Zenghui Zhang, Wenjing Yang, Changji Liu, Xiao Yu, Shuyong Song, Chengcai Xia
Abstract
Abstract Tandem reactions via electrocatalytic annulations have emerged as a strategy for the construction of heterocycles. Herein, a two‐component electrochemical annulation via sequential reduction, oxidation, and condensation steps to synthesize valuable benzimidazoles motifs is reported. This reaction, which utilizes electricity as both the oxidants and reductants, tolerates a broad range of functional groups. Detailed mechanistic studies including control experiments, cyclic voltammetry (CV) analysis, and key reaction intermediate characterization, reveals an intermolecular electrochemical redox/cyclization pathway.
Topics & Concepts
ChemistryRedoxNitrobenzeneTandemElectrochemistryCondensationCascade reactionCondensation reactionOrganic chemistryCombinatorial chemistryPhotochemistryCatalysisElectrodeThermodynamicsMaterials sciencePhysical chemistryComposite materialPhysicsElectrochemical Analysis and Applications