Febuxostat treatment attenuates oxidative stress and inflammation due to ischemia-reperfusion injury through the necrotic pathway in skin flap of animal model
Kazuya Odake, Masaya Tsujii, Takahiro Iino, Katsura Chiba, Takeshi Kataoka, Akihiro Sudo
Topics & Concepts
FebuxostatXanthine oxidaseMedicineAllopurinolXanthine oxidase inhibitorReperfusion injuryOxidative stressIschemiaNecrosisSurgeryAnesthesiaPharmacologyUrologyPathologyUric acidInternal medicineChemistryHyperuricemiaBiochemistryEnzymeReconstructive Surgery and Microvascular TechniquesCardiac Ischemia and ReperfusionOrgan Transplantation Techniques and Outcomes