Sequence of αPD-1 relative to local tumor irradiation determines the induction of abscopal antitumor immune responses
Joyce Wei, Welby Montalvo-Ortiz, Lola Yu, Amanda Krasco, Sarah Ebstein, Czrina Cortez, Israel Lowy, Andrew Murphy, Matthew A. Sleeman, Dimitris Skokos
Abstract
T cells at the irradiated tumor site generated a suboptimal systemic antitumor response and the loss of abscopal responses. Therefore, this report maximizes the potential synergy between radiotherapy and αPD-1 immunotherapy, information that will benefit clinical combinations of radiotherapy and immune checkpoint blockade.
Topics & Concepts
Abscopal effectCD8Cancer researchImmune checkpointImmune systemImmunotherapyRadiation therapyMedicineRadiosensitivityBystander effectImmunologyBlockadeInternal medicineReceptorCancer Immunotherapy and BiomarkersImmune Cell Function and InteractionImmunotherapy and Immune Responses