Multisystem Inflammatory Syndrome in Adults (MIS-A) and SARS-CoV2: An Evolving Relationship
Dominic Worku
Abstract
The SARS-CoV2 pandemic is the most significant global health emergency of the last century. While the pathophysiology of SARS-CoV2 is understood, the early and long-term outcomes of natural infection are increasingly being recognised. Multisystem inflammatory syndrome (MIS) represents a manifestation of the extreme immune dysfunction that SARS-CoV2 infection heralds and has been described in both children (MIS-C) and adults (MIS-A). Here, we discuss current knowledge of MIS-A and the vast questions that remain unanswered.
Topics & Concepts
PandemicImmune systemSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)MedicineSystemic inflammatory response syndromePathophysiologyImmunology2019-20 coronavirus outbreakIntensive care medicineDiseaseVirologyInfectious disease (medical specialty)PathologySepsisOutbreakKawasaki Disease and Coronary ComplicationsCOVID-19 Clinical Research StudiesLong-Term Effects of COVID-19