High-mobility group box 1 protein participates in acute lung injury by activating protein kinase R and inducing M1 polarization
Ruiting Li, You Shang, Yuan Yu, Ting Zhou, Wei Xiong, Xiaojing Zou
Topics & Concepts
TLR2HMGB1Protein kinase RTLR4Proinflammatory cytokineSignal transductionProtein kinase AMacrophage polarizationLipopolysaccharideCytokineCell biologyToll-like receptorChemistryReceptorInflammationBiologyKinaseInnate immune systemImmunologyIn vitroMacrophageMitogen-activated protein kinase kinaseBiochemistryAdvanced Glycation End Products researchImmune Response and InflammationS100 Proteins and Annexins