Naringenin as a Possible Candidate Against SARS-CoV-2 Infection and in the Pathogenesis of COVID-19
Pawan K. Agrawal, Chandan Agrawal, Gerald Blunden
Abstract
Naringenin, widely distributed in fruits and vegetables, is endowed with antiviral and other health beneficial activities, such as immune-stimulating and anti-inflammatory actions that could play a role in contributing, to some extent, to either preventing or alleviating coronavirus infection. Several computational studies have identified naringenin as one of the prominent flavonoids that can possibly inhibit internalization of the virus, virus-host interactions that trigger the cytokine storm, and replication of the virus. This review highlights the antiviral potential of naringenin in COVID-19 associated risk factors and its predicted therapeutic targets against SARS-CoV-2 infection.
Topics & Concepts
NaringeninCytokine stormVirusViral replicationVirologyPathogenesisCoronavirusCoronavirus disease 2019 (COVID-19)Immune systemSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)BiologyImmunologyMedicineFlavonoidInfectious disease (medical specialty)DiseaseBiochemistryAntioxidantPathologySARS-CoV-2 and COVID-19 ResearchComputational Drug Discovery MethodsAndrographolide Research and Applications