Selective degradation-inducing probes for studying cereblon (CRBN) biology
Chelsea E. Powell, Guangyan Du, Jonathan W. Bushman, Zhixiang He, Tinghu Zhang, Eric S. Fischer, Nathanael S. Gray
Abstract
Thorough compound characterization by combination western and proteomic analysis identified ZXH-4-130 and ZXH-4-137 as potent and selective small molecule degraders of cereblon (CRBN).
Topics & Concepts
CereblonDegradation (telecommunications)BiologyComputational biologyCell biologyChemistryComputer scienceGeneticsUbiquitinTelecommunicationsGeneUbiquitin ligaseProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysPlant Virus Research Studies