Manipulation of Saliva-Derived Microcosm Biofilms To Resemble Dysbiotic Subgingival Microbiota
Yaling Jiang, Bernd W. Brandt, Mark J. Buijs, Lei Cheng, R.A.M. Exterkate, Wim Crielaard, Dongmei Deng
Abstract
pathogen-enriched subgingival microbiota in severe periodontitis. This biofilm model circumvents the difficulties encountered when using subgingival plaque as the inoculum and achieves microbiota in a dysbiotic state in a controlled and reproducible manner, which is required for high-throughput and large-scale evaluation of strategies that can potentially modulate microbial ecology.
Topics & Concepts
BiofilmDysbiosisMicrobiomeMicrobiologyMicrocosmBiologyPeriodontitisSalivaDental plaqueMetagenomicsBacteriaMedicineBioinformaticsDentistryGeneticsEcologyGeneBiochemistryOral microbiology and periodontitis researchSalivary Gland Disorders and FunctionsGut microbiota and health