Enhancement of the extra-fine particle fraction of levofloxacin embedded in excipient matrix formulations for dry powder inhaler using response surface methodology
Jun Yee Tse, Kazunori Kadota, Tetsuya Imakubo, Hiromasa Uchiyama, Yuichi Tozuka
Topics & Concepts
ExcipientDry-powder inhalerResponse surface methodologyParticle sizeMaterials scienceSpray dryingVolumetric flow rateMatrix (chemical analysis)ChromatographyInhalerChemical engineeringChemistryComposite materialMedicineAsthmaEngineeringPhysicsInternal medicineQuantum mechanicsInhalation and Respiratory Drug DeliveryMicroencapsulation and Drying ProcessesAerosol Filtration and Electrostatic Precipitation