Viral expression of constitutively active AKT3 induces CST axonal sprouting and regeneration, but also promotes seizures
Thomas Campion, Imran S. Sheikh, Rupert D. Smit, Philip H. Iffland, Jie Chen, Ian P. Junker, Barbara Krynska, Peter B. Crino, George M. Smith
Topics & Concepts
AxonSTAT3PI3K/AKT/mTOR pathwayRegeneration (biology)BiologyNeuroscienceProtein kinase BRibosomal protein s6NeuriteCell biologyPhosphorylationSignal transductionP70-S6 Kinase 1BiochemistryIn vitroNerve injury and regenerationNeurogenesis and neuroplasticity mechanismsNuclear Receptors and Signaling