Quantitative parameters in novel spectral computed tomography: Assessment of Ki-67 expression in patients with gastric adenocarcinoma
Liting Mao, Wei-Cui Chen, Jian-Ye Lu, Han-Liang Zhang, Yong-Song Ye, Yu Zhang, Бо Лю, Wei‐Wei Deng, Xian Liu
Abstract
BACKGROUND: The level of Ki-67 expression has served as a prognostic factor in gastric cancer. The quantitative parameters based on the novel dual-layer spectral detector computed tomography (DLSDCT) in discriminating the Ki-67 expression status are unclear. AIM: To investigate the diagnostic ability of DLSDCT-derived parameters for Ki-67 expression status in gastric carcinoma (GC). METHODS: ) in the arterial phase (AP) and venous phase (VP) were retrospectively compared between patients with low and high Ki-67 expression in gastric adenocarcinoma. Spearman's correlation coefficient was used to analyze the association between the above parameters and Ki-67 expression status. Receiver operating characteristic (ROC) curve analysis was performed to compare the diagnostic efficacy of the statistically significant parameters between two groups. RESULTS: (AUC 0.630, 0.631 and 0.662) in discriminating the Ki-67 status. CONCLUSION: and IC may be useful parameters for evaluating the Ki-67 expression.