RIPK1-targeted therapy alleviates intervertebral disc degeneration via inhibiting nucleus pulposus PANoptosis
Zhenyu Zhu, Fanqi Kong, Feng Jiang, Jialin Jiang, Danni Quan, Jiazheng Guo, Kaiqiang Sun, Jiangang Shi, Changnan Wang, Chunlin Zhuang, Ximing Xu
Topics & Concepts
RIPK1Gene knockdownIntervertebral discProgrammed cell deathCell biologyWestern blotChemistryZebrafishKnockout mouseCancer researchApoptosisNF-κBExtracellular matrixMatrix metalloproteinaseViability assayConditional gene knockoutPathologyBiologyNucleusImmunohistochemistryNecroptosisDegeneration (medical)Signal transductionIn vitroKidneySpine and Intervertebral Disc PathologyMusculoskeletal pain and rehabilitationSpondyloarthritis Studies and Treatments