CD11c <sup>high</sup> B Cell Expansion Is Associated With Severity and Brain Atrophy in Neuromyelitis Optica
Eiichiro Amano, Wakiro Sato, Yukio Kimura, Atsuko Kimura, Youwei Lin, Tomoko Okamoto, Noriko Sato, Takanori Yokota, Takashi Yamamura
Abstract
BACKGROUND AND OBJECTIVES: B cells in the peripheral blood of patients with NMO and the clinical profiles including the brain volume. METHODS: B-cell frequency and brain atrophy. RESULTS: B-cell frequency was positively correlated with T peripheral helper-1 (Tph-1) cell frequency. DISCUSSION: B cells associated with brain atrophy and disease severity, indicating that this cell population could be involved in chronic neuroinflammation in NMO.
Topics & Concepts
Neuromyelitis opticaCD19MedicinePeripheral blood mononuclear cellAtrophyMultiple sclerosisB cellImmune systemFlow cytometryCD5AntibodyPathogenesisPathologyInternal medicineImmunologyBiologyBiochemistryIn vitroMultiple Sclerosis Research StudiesT-cell and B-cell ImmunologyImmunotherapy and Immune Responses