Recent Advances on the Antimicrobial Activities of Schiff Bases andtheir Metal Complexes: An Updated Overview
Juliana Jorge, Kristiane Fanti Del Pino Santos, Fernanda Timóteo, Rafael Rodrigo Piva Vasconcelos, Osmar Ignacio Ayala Cáceres, Isis Juliane Arantes Granja, David Monteiro de Souza, Tiago Elias Allievi Frizon, Giancarlo V. Botteselle, Antônio L. Braga, Sumbal Saba, Sumbal Saba, Haroon Ur Rashid, Haroon Ur Rashid, Jamal Rafique
Abstract
Schiff bases represent a valuable class of organic compounds, synthesized via condensation of primary amines with ketones or aldehydes. They are renowned for possessing innumerable applications in agricultural chemistry, organic synthesis, chemical and biological sensing, coating, polymer and resin industries, catalysis, coordination chemistry, and drug designing. Schiff bases contain imine or azomethine (-C=N-) functional groups which are important pharmacophores for the design and synthesis of lead bioactive compounds. In medicinal chemistry, Schiff bases have attracted immense attention due to their diverse biological activities. This review aims to encompass the recent developments on the antimicrobial activities of Schiff bases. The article summarizes the antibacterial, antifungal, antiviral, antimalarial, and antileishmanial activities of Schiff bases reported since 2011.