Influence of nanoparticle size on blood–brain barrier penetration and the accumulation of anti-seizure medicines in the brain
Qian Meng, Hongmei Meng, Yong Pan, Jiayu Liu, Jiaai Li, Yanxin Qi, Yubin Huang
Abstract
nanoparticles possessed the highest cell uptake efficiency. The endocytosis efficiency was 90% at 30 min, which far exceeded that of the other groups. Moreover, similar results were obtained from subsequent experiments where fluorescence images of the isolated organs of the mice were acquired. To summarize, our study demonstrated that drug delivery to the brain using nanocarriers is size dependent. Nanoparticles with the smallest particle size can be internalized more effectively, and easily penetrate the BBB, and accumulate in the brain.
Topics & Concepts
NanocarriersEndocytosisNanoparticlePharmacologyBlood–brain barrierDrug deliveryPLGAEthylene glycolIn vivoBiodistributionDrugMaterials scienceNanotechnologyBiophysicsChemistryCellMedicineIn vitroBiochemistryCentral nervous systemInternal medicineOrganic chemistryBiologyBiotechnologyAdvanced Drug Delivery SystemsDrug Transport and Resistance MechanismsNanoparticle-Based Drug Delivery