Global Cellular Metabolic Rewiring Adapts Corynebacterium glutamicum to Efficient Nonnatural Xylose Utilization
Xi Sun, Yufeng Mao, Jiahao Luo, Pi Liu, Meiru Jiang, Guimei He, Zhidan Zhang, Qichen Cao, Jie Shen, Hongwu Ma, Tao Chen, Zhiwen Wang
Abstract
A novel xylose regulatory mechanism mediated by the transcription factor IpsA was revealed. A synergistic effect on carbon metabolism and energy supply was found to endow C. glutamicum with the efficient xylose utilization and rapid growth phenotype. The new xylose regulatory mechanism enriches the understanding of nonnatural substrate metabolism and encourages exploration new engineering targets for rapid xylose utilization. This work also provides a paradigm to understand and engineer the metabolism of nonnatural renewable substrates for sustainable biomanufacturing.
Topics & Concepts
Corynebacterium glutamicumXyloseXylose metabolismTranscription factorBiochemistryBiologyBacteriaPhenotypeComputational biologyChemistryGeneGeneticsFermentationMicrobial Metabolic Engineering and BioproductionBiofuel production and bioconversionEnzyme Catalysis and Immobilization