A smart probe for simultaneous imaging of the lipid/water microenvironment in atherosclerosis and fatty liver
Zixuan Zhan, Weihua Zhuang, Qian Lei, Shufen Li, Wuyu Mao, Mao Chen, Weimin Li
Abstract
A smart lipid droplet specific fluorescent probe (LDs-DM) with dual-emission in water (706 nm) and oil (535 nm) under single-excitation was prepared for revealing the ultra-structure of the aqueous and lipidic microenvironment in living cells, fatty liver tissues and atherosclerotic plaques without fluorescence emission crosstalk. This work is expected to provide inspiration for designing a novel probe with color switching ability.
Topics & Concepts
FluorescenceCrosstalkChemistryLipid dropletFatty liverBiophysicsNanotechnologyBiochemistryMaterials sciencePathologyBiologyMedicineOpticsPhysicsDiseaseLipid metabolism and biosynthesisFatty Acid Research and HealthMetabolomics and Mass Spectrometry Studies