Impact of SARS-CoV-2 variants on the total CD4+ and CD8+ T cell reactivity in infected or vaccinated individuals
Alison Tarke, John Sidney, Nils Methot, Esther Dawen Yu, Yun Zhang, Jennifer M. Dan, Benjamin Goodwin, Paul Rubiro, Aaron Sutherland, Eric Wang, April Frazier, Sydney I. Ramirez, Stephen A. Rawlings, Davey M. Smith, Ricardo da Silva Antunes, Bjoern Peters, Richard H. Scheuermann, Daniela Weiskopf, Shane Crotty, Alba Grifoni, Alessandro Sette
Abstract
T cell epitopes, respectively, are affected by mutations in the various VOCs. Thus, the SARS-CoV-2 variants analyzed here do not significantly disrupt the total SARS-CoV-2 T cell reactivity; however, the decreases observed highlight the importance for active monitoring of T cell reactivity in the context of SARS-CoV-2 evolution.
Topics & Concepts
VirologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakBiologyCD8MedicineImmunologyOutbreakImmune systemDiseasePathologyInfectious disease (medical specialty)SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesLong-Term Effects of COVID-19