Total synthesis of crotophorbolone
Tianzi Yu, Ying Sun, Canhui Tu, Ting Chen, Shaomin Fu, Bo Liu
Abstract
Convergent total synthesis of crotophorbolone was accomplished in 18 longest linear steps. Observation of unexpected thermodynamic stability of a <italic>cis,trans</italic>-5/7/6 tricycle would benefit synthetic design of tigliane- and daphnane-related diterpenoids.
Topics & Concepts
Total synthesisStereochemistryMathematicsChemistryBioactive Natural Diterpenoids ResearchMarine Sponges and Natural ProductsBiological Activity of Diterpenoids and Biflavonoids