Intestinal UDP-Glucuronosyltransferase 1A1 and Protection against Irinotecan-Induced Toxicity in a Novel UDP-Glucuronosyltransferase 1A1 Tissue-Specific Humanized Mouse Model
Elvira Mennillo, Xiaojing Yang, André Alberto Weber, Yoshihiro Maruo, Mélanie Verreault, Olivier Barbier, Shujuan Chen, Robert H. Tukey
Topics & Concepts
PharmacologyIn vivoEndoplasmic reticulumApoptosisIrinotecanOrganoidBiologyChemistryBiochemistryCell biologyCancerBiotechnologyColorectal cancerGeneticsCancer therapeutics and mechanismsPharmacogenetics and Drug MetabolismDrug Transport and Resistance Mechanisms