Corn distillers solubles as a novel bioresource of bioactive peptides with ACE and DPP IV inhibition activity: characterization, <i>in silico</i> evaluation, and molecular docking
Sonu Sharma, Ranjan Pradhan, Annamalai Manickavasagan, Mahendra Thimmanagari, Animesh Dutta
Abstract
Alcalase was found to be the best enzyme for CDS and the protein hydrolysates produced showed superior inhibition of ACE (98.76 ± 1.28%) and DPP IV (34.99 ± 1.44%). Bioinformatic tools demonstrated potential anti-ACE and anti-DPP IV peptides.
Topics & Concepts
In silicoChemistryDocking (animal)BiochemistryCombinatorial chemistryMedicineGeneNursingProtein Hydrolysis and Bioactive PeptidesInsect Utilization and EffectsComputational Drug Discovery Methods