Epithelioid malignant peripheral nerve sheath tumor arising in schwannoma
Nicholas Heatley, Eva Kolson Kokohaare, D. Strauß, Magnus Hällin, Robin L. Jones, Cyril Fisher, Khin Thway
Abstract
Epithelioid malignant peripheral nerve sheath tumor (EMPNST, malignant epithelioid schwannoma) is a rare variant of malignant peripheral nerve sheath tumor that has morphologic and immunophenotypic overlap with a variety of epithelioid neoplasms. Because of its rarity it may be potentially underrecognized. We describe a case arising in the subcutis of the thigh in a 25 year-old female, and discuss the pathologic features and differential diagnosis.
Topics & Concepts
MedicineSchwannomaMalignant peripheral nerve sheath tumorPathologyNerve sheathEpithelioid cellNerve sheath neoplasmThighDifferential diagnosisPeripheral nervePeripheralAnatomyImmunohistochemistryInternal medicineNeurofibromatosis and Schwannoma CasesTumors and Oncological CasesVascular Tumors and Angiosarcomas