Ginsenoside CK improves skeletal muscle insulin resistance by activating DRP1/PINK1-mediated mitophagy
Weili Li, Haiyang Li, Lujuan Zheng, Jing Xia, Xiaoxuan Yang, Shuhan Men, Ye Yuan, Yuying Fan
Abstract
), which was based on mitophagy activation. After the knockdown of mitophagy-related receptors, we found that DRP1/PINK1 was the key pathway of CK-induced mitophagy. These findings indicated that ginsenoside CK is a promising lead compound against diabetes.
Topics & Concepts
MitophagyInsulin resistanceSkeletal muscleGLUT4MitochondrionMitochondrial fissionChemistryMyocyteInternal medicineCell biologyGlycogenInsulinEndocrinologyBiologyBiochemistryAutophagyMedicineApoptosisAutophagy in Disease and TherapyGinseng Biological Effects and ApplicationsCalcium signaling and nucleotide metabolism