Injectable hydrogel with dual-sensitive behavior for targeted delivery of oncostatin M to improve cardiac restoration after myocardial infarction
Yong‐Liang Jiang, Shiwei Niu, Zhi Lin, Limei Li, Ping Yang, Peng Rao, Lin Yang, Lihong Jiang, Lin Sun
Abstract
, the OSM-loaded hydrogel exhibited continuous and localized release of OSM in response to specific pH and changes in MI rats, thereby accelerating angiogenesis and proliferation of cardiomyocytes, inhibiting myocardial fibrosis and improving cardiac function effectively. This study may provide a new perspective for the application of dual-sensitive hydrogels clinically, especially in tissue engineering for MI repair and drug delivery.
Topics & Concepts
Oncostatin MMyocardial infarctionMaterials scienceBiomedical engineeringDual (grammatical number)MedicineCardiologyInternal medicineInterleukin 6CytokineLiteratureArtCardiac Fibrosis and RemodelingPeptidase Inhibition and AnalysisSignaling Pathways in Disease