Krüppel-like Factor 2 (KLF2) in Immune Cell Migration
Jens Wittner, Wolfgang Schuh
Abstract
Krüppel-like factor 2 (KLF2), a transcription factor of the krüppel-like family, is a key regulator of activation, differentiation, and migration processes in various cell types. In this review, we focus on the functional relevance of KLF2 in immune cell migration and homing. We summarize the key functions of KLF2 in the regulation of chemokine receptors and adhesion molecules and discuss the relevance of the KLF2-mediated control of immune cell migration in the context of immune responses, infections, and diseases.
Topics & Concepts
KLF2KrüppelImmune systemContext (archaeology)Cell migrationCell biologyHoming (biology)Cell adhesion moleculeTranscription factorBiologyComputational biologyCellImmunologyGeneticsGeneEcologyPaleontologyKruppel-like factors researchChronic Myeloid Leukemia TreatmentsGenetic Syndromes and Imprinting