Surfactant-chaperoned donor–acceptor–donor NIR-II dye strategy efficiently circumvents intermolecular aggregation to afford enhanced bioimaging contrast
Tianyang Han, Yajun Wang, Jiajun Xu, Ningning Zhu, Lang Bai, Xiangping Liu, Bin Sun, Chenlong Yu, Qinglun Meng, Jiaqi Wang, Qi Su, Qing Cai, Kenneth S. Hettie, Yuewei Zhang, Shoujun Zhu, Bai Yang
Abstract
bioimaging applications. In parallel, we also investigate the D-A-D dye uptake and signal enhancement properties in the liver of murine models and demonstrate that the lumen-lining Kupffer cells can potentially disassemble PEGylated D-A-D aggregates such that their inherent brightness is restored. This phenomenon is similar to the surfactant-chaperoned dye strategy and our investigations provide a positive addition to better use of the current NIR-II fluorophores, especially for visualizing high-brightness required events.
Topics & Concepts
Pulmonary surfactantIntermolecular forceAcceptorPEGylationPhotochemistryMaterials scienceChemistryNanotechnologyMoleculePolyethylene glycolOrganic chemistryBiochemistryPhysicsCondensed matter physicsNanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsAdvanced biosensing and bioanalysis techniques