FBXL4 mutations cause excessive mitophagy via BNIP3/BNIP3L accumulation leading to mitochondrial DNA depletion syndrome
Yingji Chen, Dongyue Jiao, Yang Liu, Xiayun Xu, Yilin Wang, Xiaona Luo, Hexige Saiyin, Yao Li, Kun Gao, Yucai Chen, Shimin Zhao, Lixiang Ma, Chenji Wang
Topics & Concepts
MitophagyCell biologyMitochondrionBiologyUbiquitin ligaseMitochondrial DNAUbiquitinMutationOxidative phosphorylationAutophagyGeneticsBiochemistryGeneApoptosisMitochondrial Function and PathologyUbiquitin and proteasome pathwaysAutophagy in Disease and Therapy