The Oncogenic Helicase ALC1 Regulates PARP Inhibitor Potency by Trapping PARP2 at DNA Breaks
Charlotte Blessing, Imke K. Mandemaker, Claudia Gonzalez-Leal, Julia Preißer, Adrian Schomburg, Andreas G. Ladurner
Topics & Concepts
PARP1BiologyDNA damageChromatinPARP inhibitorCell biologyPoly ADP ribose polymeraseRecQ helicaseHelicaseDNAG2-M DNA damage checkpointDNA repairOlaparibPolymeraseSynthetic lethalityHomologous recombinationCancer researchMolecular biologyGenome instabilityCancerGeneticsCell cycle checkpointCell cycleRNAGenePARP inhibition in cancer therapyDNA Repair MechanismsCRISPR and Genetic Engineering