Quantitative phosphoproteomic analysis reveals involvement of PD-1 in multiple T cell functions
Anna S. Tocheva, Michael Peled, Marianne Strazza, Kieran Adam, Shalom Lerrer, Shruti Nayak, Inbar Azoulay‐Alfaguter, Connor Foster, Elliot A. Philips, Benjamin G. Neel, Beatrix Ueberheide, Adam Mor
Abstract
predictions revealed that kinase/substrate relationships engaged downstream of PD-1 ligation. These insights uncover the phosphoproteomic landscape of PD-1-triggered pathways and reveal novel PD-1 substrates that modulate diverse T cell functions and may serve as future therapeutic targets. These data are a useful resource in the design of future PD-1-targeting therapeutic approaches.
Topics & Concepts
Computational biologyCellChemistryBiologyCell biologyBiochemistryCancer Immunotherapy and BiomarkersImmunotherapy and Immune ResponsesCAR-T cell therapy research