Choline and trimethylamine N-oxide impair metabolic activation of and platelet response to clopidogrel through activation of the NOX/ROS/Nrf2/CES1 pathway
Peng‐Xin Ge, Ting Tai, Li‐Ping Jiang, Jin‐Zi Ji, Qiong‐Yu Mi, Ting Zhu, Yifei Li, Hong‐Guang Xie
Topics & Concepts
ClopidogrelChemistryPlatelet activationP2Y12PharmacologyMetaboliteApocyninPlateletTrimethylamine N-oxideBiochemistryNADPH oxidaseInternal medicineReactive oxygen speciesMedicineTrimethylamineAspirinAntiplatelet Therapy and Cardiovascular DiseasesGut microbiota and healthPlatelet Disorders and Treatments